منابع مشابه
Reinventing cancer cell metabolism.
In today’s media world, when journal publications seem at times to be outdated by the time they appear in print, oncologists are fascinated to find that experiments reported some 80 years ago could be the object of surprising new discoveries. And yet, that is precisely the setting for the CCR Focus published in this issue of Clinical Cancer Research. In 1931, Otto Warburg (top photo) was awarde...
متن کاملEndothelial cell metabolism: parallels and divergences with cancer cell metabolism
The stromal vasculature in tumors is a vital conduit of nutrients and oxygen for cancer cells. To date, the vast majority of studies have focused on unraveling the genetic basis of vessel sprouting (also termed angiogenesis). In contrast to the widely studied changes in cancer cell metabolism, insight in the metabolic regulation of angiogenesis is only just emerging. These studies show that met...
متن کاملCancer cell metabolism: one hallmark, many faces.
Cancer cells must rewire cellular metabolism to satisfy the demands of growth and proliferation. Although many of the metabolic alterations are largely similar to those in normal proliferating cells, they are aberrantly driven in cancer by a combination of genetic lesions and nongenetic factors such as the tumor microenvironment. However, a single model of altered tumor metabolism does not desc...
متن کاملRewiring of glycolysis in cancer cell metabolism.
Altered metabolism constitutes a nearly universal feature of cancer cells. This metabolic reorganization in part originates from the high proliferative state displayed by cancer cells. The nature of this altered metabolism is complex with multiple strategies implemented across diverse contextual dependencies to enable the accumulation of the biomass that is necessary for proliferation in a stre...
متن کاملTargeting cancer cell metabolism in pancreatic adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is expected to become the second leading cause of cancer death by 2030. Current therapeutic options are limited, warranting an urgent need to explore innovative treatment strategies. Due to specific microenvironment constraints including an extensive desmoplastic stroma reaction, PDAC faces major metabolic challenges, principally hypoxia and nutrient depr...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Symposia on Quantitative Biology
سال: 2011
ISSN: 0091-7451,1943-4456
DOI: 10.1101/sqb.2011.76.012856